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November 2003

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Classification, clustering, and phylogeny estimation
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Tue, 25 Nov 2003 10:31:55 -0500
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Herman Wold's Theoretical Empiricism (1989) might be helpful...
Best,
Tom




                     shannon
                     <[log in to unmask]        To:     [log in to unmask]
                     USTL.EDU>              cc:     (bcc: Thomas Ball/NYO/NorthAmerica/MCKINSEY)
                     Sent by:               Subject:
                     "Classification
                     , clustering,
                     and phylogeny
                     estimation"
                     <[log in to unmask]
                     sunysb.edu>
                     11/25/2003
                     09:48 AM
                     Please respond
                     to
                     "Classification
                     , clustering,
                     and phylogeny
                     estimation"






Can anyone get me started in the literature on the 'small n, large p'
problem?

A couple of references would be helpful.


The problem I am faced with are consultee's who do not understand why a
simple logistic model is wrong with n = 50 (say 25 cases 25 controls) and
the number of variables (p) equal to tens of thousnads (say gene
expressions or whole genome genotypes).

(I try to explain about 50 data points embedded in a very high dimensional
space but they generally start getting that glaxzed look in their eyes.)


Bill
---

William D. Shannon, Ph.D.

Assistant Professor of Biostatistics in Medicine
Division of General Medical Sciences and Biostatistics

Washington University School of Medicine
Campus Box 8005, 660 S. Euclid
St. Louis, MO   63110

Phone: 314-454-8356
Fax: 314-454-5113
e-mail: [log in to unmask]
web page: http://ilya.wustl.edu/~shannon



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