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| Reply To: | Classification, clustering, and phylogeny estimation |
| Date: | Tue, 25 Nov 2003 10:31:55 -0500 |
| Content-Type: | text/plain |
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Herman Wold's Theoretical Empiricism (1989) might be helpful...
Best,
Tom
shannon
<[log in to unmask] To: [log in to unmask]
USTL.EDU> cc: (bcc: Thomas Ball/NYO/NorthAmerica/MCKINSEY)
Sent by: Subject:
"Classification
, clustering,
and phylogeny
estimation"
<[log in to unmask]
sunysb.edu>
11/25/2003
09:48 AM
Please respond
to
"Classification
, clustering,
and phylogeny
estimation"
Can anyone get me started in the literature on the 'small n, large p'
problem?
A couple of references would be helpful.
The problem I am faced with are consultee's who do not understand why a
simple logistic model is wrong with n = 50 (say 25 cases 25 controls) and
the number of variables (p) equal to tens of thousnads (say gene
expressions or whole genome genotypes).
(I try to explain about 50 data points embedded in a very high dimensional
space but they generally start getting that glaxzed look in their eyes.)
Bill
---
William D. Shannon, Ph.D.
Assistant Professor of Biostatistics in Medicine
Division of General Medical Sciences and Biostatistics
Washington University School of Medicine
Campus Box 8005, 660 S. Euclid
St. Louis, MO 63110
Phone: 314-454-8356
Fax: 314-454-5113
e-mail: [log in to unmask]
web page: http://ilya.wustl.edu/~shannon
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