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November 2003

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Subject:
From:
shannon <[log in to unmask]>
Reply To:
Classification, clustering, and phylogeny estimation
Date:
Tue, 25 Nov 2003 08:48:54 -0600
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Can anyone get me started in the literature on the 'small n, large p'
problem?

A couple of references would be helpful.


The problem I am faced with are consultee's who do not understand why a
simple logistic model is wrong with n = 50 (say 25 cases 25 controls) and
the number of variables (p) equal to tens of thousnads (say gene
expressions or whole genome genotypes).

(I try to explain about 50 data points embedded in a very high dimensional
space but they generally start getting that glaxzed look in their eyes.)


Bill
---

William D. Shannon, Ph.D.

Assistant Professor of Biostatistics in Medicine
Division of General Medical Sciences and Biostatistics

Washington University School of Medicine
Campus Box 8005, 660 S. Euclid
St. Louis, MO   63110

Phone: 314-454-8356
Fax: 314-454-5113
e-mail: [log in to unmask]
web page: http://ilya.wustl.edu/~shannon

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